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Nutrition Facts
Serving Size: 3 Capsules

Amount Per Serving

% Daily Value *
Vitamin B-6 5 mg  250%
Artichoke Extract
(Cynara scolymus) (leaf) (5% total caffeoylquinic acids)
900 mg *
Coleus Forskohlii (root) extract
(Standardized for 20% forskolin - 4 mg)
20 mg *
L-Phenylalanine 500 mg *
Acetyl-L-Carnitine 750 mg *
* Percent daily values are based on a 2000 calorie diet
  † Daily Value not established
Note: Serving Sizes are rounded to the nearest whole serving


Suggested usage: For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day.  

Natural Stacks CILTEP

Natural Stacks CILTEP is a natural nootropic that combines artichoke extract and forskolin to naturally induce long-term potentiation.* CILTEP® is a healthy way to stay focused, alert, and motivated for hours.*

The benefits include:

  • May increase motivation and mental endurance*
  • May increase ability to study and retain information*
  • May improve concentration and long-term memory*
  • May improve mood and social ease*

CILTEP is used every day by thousands of people around the world, including CEOs, Wall Street Executives, college students, scientists and creatives.

One bottle contains 60 capsules.

Long-Term Potentiation

CILTEP works by naturally inducing Long-Term Potentiation (LTP), one of the major cellular mechanisms behind learning and memory.* Memories are formed or “encoded” in the brain by creating LTP.

Premium Artichoke Extract

Artichoke extract contains Luteolin, a safe natural inhibitor of PDE4. PDE4 inhibitors may result in increased cognition, improved long term memory, increased wakefulness, and neuroprotection.*

Forskolin Derived from Coleus Forskohlii

Forskolin activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP. The result is it could potentially improve overall cognitive function, especially memory formation and retention of new information.*

CILTEP works by naturally inducing Long-Term Potentiation.

Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time.* LTP is one of the major cellular mechanisms behind learning and memory. Memories are formed or “encoded” in the brain by creating LTP.

CILTEP achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).

PDE4 Inhibition

PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells.* PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition, improved long term memory, increased wakefulness, and neuroprotection.*

There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory

CILTEP & Neurotransmitters

CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes.* Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as Adderall or Ritalin).

L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine and acetylcholine. These natural nutrients synergize perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.*

Artichoke Extract

Artichoke Extract contains Luteolin which is a natural inhibitor of the enzyme PDE4.* This enzyme is present in neurons where it breaks down CREB activating cAMP. CREB activation is important for long-term potentiation, a process vital to learning and memory. Inhibiting PDE4 and thus increasing cAMP levels in neurons has been shown to increase long-term potentiation.*


Forskolin is derived from the plant Coleus forskohlii and is used in traditional Indian Ayurvedic medicine. It has the property of increasing levels of cAMP in cells. Combined with Luteolin from Artichoke extract, forskolin synergistically increases the duration and levels of cAMP in neurons.*


L-Phenylalanine is an essential amino acid present in many foods. When CREB is activated studies have shown that transcription of the enzyme tyrosine hydroxylase is increased leading to an increased rate of dopamine metabolism.* L-Phenylalanine is the natural precursor to dopamine and thus helps supply the necessary amino acid fuel for that metabolism.*

Acetyl-L-Carnitine (ALCAR)

ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver.

Vitamin B6

Vitamin B6 is an essential vitamin and an important enzymatic cofactor that helps the body produce essential neurotransmitters including dopamine, serotonin, and GABA. It helps activate DOPA decarboxylase, an enzyme directly downstream from tyrosine hydroxylase in dopamine metabolism and thus helps to maintain optimal dopamine metabolism under conditions of increased Tyrosine Hydroxylase that occur during CREB enhanced LTP.*


These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.