This medication is typically used for pain, to reduce fever or to assist in the treatment of heart attacks. It may also be used for rheumatoid arthritis, for the prevention of transient cerebral ischemia (a brief loss of oxygen to the brain) or stroke, as well as for other uses. Entrophen is a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting several different chemical processes. Entrophen is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches.